Twelve‐component pharmacokinetic study of rat plasma after oral administration of You‐Gui‐Wan in osteoporosis rats with kidney‐yin deficiency and kidney‐yang deficiency

Abstract You‐Gui‐Wan is a widely used traditional Chinese medicine preparation for the treatment of osteoporosis with kidney‐yang deficiency, and is composed of both yang‐invigorating and kidney‐tonifying herbs, and yin‐nourishing and kidney essence‐replenishing herbs. Considering that the pharmacokinetics of drugs might differ in different pathological conditions, it is necessary to study the pharmacokinetic characteristics of You‐Gui‐Wan under different osteoporotic conditions. In this study, the pharmacokinetic behaviors of You‐Gui‐Wan in osteoporosis rats with kidney‐yin and kidney‐yang deficiency were compared. The results showed that the absorption, metabolism, and disposition of You‐Gui‐Wan varied widely in animals with different types of osteoporosis. The active components belonging to the yang‐invigorating herbs, such as aconitine, hypaconitine, mesaconitine, benzoylaconine, benzoylhypacoitine, benzoylmesaconine, chlorogenic acid and pinoresinol diglucoside, had a higher uptake and slower elimination in osteoporosis rats with kidney‐yang deficiency, which corresponds to the opinion that You‐Gui‐Wan is used to treat kidney‐yang deficiency syndrome, and indicates the scientific nature of Bian‐Zheng‐Lun‐Zhi.