对映选择合成
路易斯酸
沮丧的刘易斯对
手性路易斯酸
化学
有机催化
分子内力
组合化学
催化作用
立体化学
有机化学
作者
Michael G. Guerzoni,Ayan Dasgupta,Emma Richards,Rebecca L. Melen
出处
期刊:Chem catalysis
[Elsevier]
日期:2022-11-01
卷期号:2 (11): 2865-2875
被引量:2
标识
DOI:10.1016/j.checat.2022.09.007
摘要
The field of asymmetric catalysis has witnessed tremendous development since its discovery, and this has recently culminated in the Nobel prize given to Benjamin List and David MacMillan “for the development of asymmetric organocatalysis.” In this perspective, we aim to highlight a less-represented class of catalysts, which can be also employed in enantioselective transformations: cooperative main-group Lewis acids and Lewis bases. Since 2007, this concept has been strongly associated with the term frustrated Lewis pair (“FLP”). Chiral FLPs have been applied in hydrogenation reactions whereby the enantioselective transformation is accomplished by using an FLP containing either a chiral Lewis acid or a chiral Lewis base. Chiral intramolecular FLPs have also been employed for this purpose. This perspective will look at the recent developments in enantioselective FLP catalysis and will suggest new directions for the field, taking inspiration from the ongoing research in the area of enantioselective cooperative catalysis.
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