N6-甲基腺苷
生物
RNA甲基化
甲基转移酶
核糖核酸
甲基化
信使核糖核酸
小RNA
癌症研究
环状RNA
遗传学
细胞生物学
癌变
非编码RNA
计算生物学
基因敲除
基因沉默
基因
作者
Tianyi Wang,Shan Kong,Tao Mei,Shaoqing Ju
标识
DOI:10.1186/s12943-020-01204-7
摘要
Abstract N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METTL3/14, WTAP, RBM15/15B, VIRMA and ZC3H13, termed “writers”), removed by demethylases (FTO, ALKBH5, and ALKBH3, termed “erasers”), and recognized by m6A-binding proteins (YTHDC1/2, YTHDF1/2/3, IGF2BP1/2/3, HNRNP, and eIF3, termed “readers”). Accumulating evidence suggests that m6A RNA methylation greatly impacts RNA metabolism and is involved in the pathogenesis of many kinds of diseases, including cancers. In this review, we focus on the physiological functions of m6A modification and its related regulators, as well as on the potential biological roles of these elements in human tumors.
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