表型筛选
药物发现
仿形(计算机编程)
表型
信息学
计算生物学
高含量筛选
药品
药物开发
数据科学
计算机科学
生物
生物信息学
遗传学
药理学
政治学
基因
法学
细胞
操作系统
作者
Scott J. Warchal,Asier Unciti‐Broceta,Neil O. Carragher
出处
期刊:Future Medicinal Chemistry
[Newlands Press Ltd]
日期:2016-07-01
卷期号:8 (11): 1331-1347
被引量:37
标识
DOI:10.4155/fmc-2016-0025
摘要
Phenotypic drug discovery (PDD) strategies are defined by screening and selection of hit or lead compounds based on quantifiable phenotypic endpoints without prior knowledge of the drug target. We outline the challenges associated with traditional phenotypic screening strategies and propose solutions and new opportunities to be gained by adopting modern PDD technologies. We highlight both historical and recent examples of approved drugs and new drug candidates discovered by modern phenotypic screening. Finally, we offer a prospective view of a new era of PDD underpinned by a wealth of technology advances in the areas of in vitro model development, high-content imaging and image informatics, mechanism-of-action profiling and target deconvolution.
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