体内
化学
效力
体外
组合化学
钌
过渡金属
药物发现
药品
药理学
纳米技术
生物化学
材料科学
生物技术
生物
催化作用
作者
Jiaxin Liang,Hai‐Jing Zhong,Guan‐Jun Yang,Kasipandi Vellaisamy,Dik‐Lung Ma,Chung‐Hang Leung
标识
DOI:10.1016/j.jinorgbio.2017.06.002
摘要
The often severe side effects displayed by currently used platinum and ruthenium complexes have motivated researchers to design and develop transition metal-based anti-tumor agents with reduced toxicity. Distinct from organic anti-tumor drugs, transition metal complexes possess several properties that render them as promising scaffolds for anti-cancer drug discovery. While a vast number of metal complexes have been synthesized and reported to be promising and potent in vitro anticancer active compounds, fewer have shown efficacy in in vivo models. The demonstration of in vivo potency is an essential step for lead candidates for clinical trials. In this review, we highlight examples of transition metal-based complexes that have shown in vivo anti-tumor activities that have been described in recent years.
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