生物膜
一氧化氮
抗菌剂
抗生素
免疫系统
细胞内
化学
细胞毒性
细菌
抗药性
抗生素耐药性
微生物学
生物
免疫学
体外
生物化学
有机化学
遗传学
作者
Mingke Yuan,Tao Sun,Jianbing Wu,Yue Fei,Yueqi Yang,Yong Ling,Yihua Zhang,Zhangjian Huang
标识
DOI:10.2174/1568026621666210701113043
摘要
Biofilms are among the most important causes of nosocomial and recurrent infections as biofilms confer antibiotic resistance to pathogenic bacteria and protect them from the host's immune system. Thus, it is imperative to investigate effective therapeutic agents to counteract biofilms. As an important signaling molecule, Nitric Oxide (NO) plays a crucial role in various biological and pathological processes. NO could disperse biofilm and restore the drug sensitivity by reducing intracellular cyclic-diguanosine monophosphate (c-di-GMP) levels. This review highlights recent advances on antibacterial and antibiofilm effects of NO when NO was co-administered with other antimicrobial agents. A significant improvement in drug permeability and biofilm cell targeting and reduced cytotoxicity could be attained with this strategy. In this review, we briefly lay out challenges and propose future directions in this appealing avenue of research on NO-based therapy for biofilm eradication.
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