药物输送
脊髓损伤
再生(生物学)
自愈水凝胶
医学
灵活性(工程)
神经科学
临床试验
脚手架
纳米技术
生物医学工程
脊髓
病理
生物
材料科学
数学
统计
高分子化学
细胞生物学
作者
Johra Khan,Mithun Rudrapal,Eijaz Ahmed Bhat,Ahmad Ali,Mohammad Alaidarous,Bader Alshehri,Saeed Banwas,Randa Mohamed Ismail,Chukwuebuka Egbuna
标识
DOI:10.3389/fbioe.2021.724158
摘要
The significance of biomaterials is well appreciated in nanotechnology, and its use has resulted in major advances in biomedical sciences. Although, currently, very little data is available on the clinical trial studies for treatment of neurological conditions, numerous promising advancements have been reported in drug delivery and regenerative therapies which can be applied in clinical practice. Among the commonly reported biomaterials in literature, the self-assembling peptides and hydrogels have been recognized as the most potential candidate for treatment of common neurological conditions such as Alzheimer's, Parkinson's, spinal cord injury, stroke and tumors. The hydrogels, specifically, offer advantages like flexibility and porosity, and mimics the properties of the extracellular matrix of the central nervous system. These factors make them an ideal scaffold for drug delivery through the blood-brain barrier and tissue regeneration (using stem cells). Thus, the use of biomaterials as suitable matrix for therapeutic purposes has emerged as a promising area of neurosciences. In this review, we describe the application of biomaterials, and the current advances, in treatment of statistically common neurological disorders.
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