Palladium‐Catalyzed ortho‐Halogenation of Tertiary Benzamides

Abstract A general and efficient protocol for the synthesis of ortho ‐halogenated tertiary benzamides under mild conditions is described. Benzamides with various functional groups underwent ortho ‐iodination, bromination or chlorination with NXS using a cationic palladium catalyst generated in situ from Pd(OAc) 2 and TfOH in DME. Given the generality, efficiency, mild conditions, and readily available catalyst and halogenation reagents, this method could provide a practical approach for the synthesis of ortho ‐halogenated benzamides.