颗粒酶B
妊娠期糖尿病
白细胞介素2受体
医学
免疫系统
FOXP3型
免疫学
超重
外周血单个核细胞
流式细胞术
穿孔素
Treg细胞
内科学
内分泌学
肥胖
妊娠期
生物
T细胞
CD8型
怀孕
体外
生物化学
遗传学
作者
Thalita Frutuoso Lobo,Cannila de Moraes Borges,Rosiane Mattar,Caio Perez Gomes,Ana G.S. Angelo,Karen Priscilla Tezotto Pendeloski,Sílvia Daher
摘要
Maternal obesity is frequently associated with gestational diabetes mellitus (GDM), and immunological mechanisms seem to be involved in the physiopathology of these conditions. The aim of this study was to characterize the profile of immune cells in peripheral blood of overweight women with GDM.This case-control study included 27 glucose-tolerant (controls) and 31 GDM overweight pregnant women. Flow cytometry was used to assess the number of regulatory T cells (Treg) and natural killer (NK) cells in the peripheral blood. In addition, the expression of IL-10, TGF-B, and TNF-A in Treg and expression of IFN-G, TNF-A, granzyme, and perforin in NK cells were analyzed.GDM patients had significantly lower frequency of TCD4+ CD25bright and TCD4+ CD25+ FOXP3high cells, higher production of TNF-A by Treg cells and higher percentage of NKCD16+ 56dim cells than the controls.The association between obesity and GDM is a condition where it is observed impaired Treg and NK cells profile, findings that seem to be related with the development of IR and inflammation.
科研通智能强力驱动
Strongly Powered by AbleSci AI