硫黄
对映选择合成
化学
级联
蒂奥-
生物催化
水介质
有机化学
一锅法合成
级联反应
反应条件
组合化学
催化作用
光催化
水溶液
反应机理
色谱法
作者
Kate Lauder,Anita Toscani,Yuyin Qi,Jesmine Lim,Simon J. Charnock,Krupa Korah,Daniele Castagnolo
标识
DOI:10.1002/anie.201802135
摘要
Abstract The synthesis of enantiomerically pure 1,3‐mercaptoalkanol volatile sulfur compounds through a one‐pot photo‐biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one‐pot cascade reaction combining photocatalytic thio‐Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3‐mercaptoalkanols in high yields with excellent enantioselectivity.
科研通智能强力驱动
Strongly Powered by AbleSci AI