任天堂
吡非尼酮
博莱霉素
肺纤维化
医学
氧化应激
药理学
特发性肺纤维化
纤维化
肺
植物疗法
体内
细胞外基质
薄壁组织
癌症研究
病理
内科学
化疗
生物
生物技术
生物化学
替代医学
作者
Sana Bahri,Ridha Ben Ali,Anouar Abidi,Saloua Jameleddine
标识
DOI:10.1016/j.biopha.2017.06.052
摘要
Pulmonary fibrosis (PF) is a lethal, chronic and progressive respiratory disease leading to interstitial lung damage and serious breathing problems. The pathogenic mechanism involves activation, migration, proliferation and differentiation of fibroblasts into myofibroblats inducing extracellular matrix accumulation that destroy lung parenchyma. Available antifibrotic treatment options are limited to Pirfenidone and Nintedanib that prevent deterioration without an improvement of this disease. The use of plant extracts and natural bioactive compounds for the treatment of PF has been known for more than thirty years in China. Nowadays, phytotherapy has gained a considerable attention in the treatment of PF both in vivo and in vitro using bleomycin (BLM)-induced lung inflammation, oxidative stress and pulmonary fibrosis in rats. In this review, we aimed to focus on the protective effects and the mechanisms of action of several plant extracts described by various research works for the treatment of PF.
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