化学
催化作用
镍
芳基
烷基
卤素
一氧化碳
配体(生物化学)
环异构化
碘化物
有机化学
组合化学
碳纤维
复合材料
受体
材料科学
复合数
生物化学
作者
Hyung Yoon,Austin D. Marchese,Mark Lautens
摘要
A novel nickel-catalyzed cycloisomerization reaction forming a new carbon–carbon bond while preserving the carbon–halogen bond has been developed. A cheap and readily available Ni-catalyst is employed to generate nitrogen containing heterocycles in good to excellent yields and the procedure is readily scalable. The more readily available aryl bromides were also cyclized with the addition of potassium iodide to generate the respective alkyl iodides. A rare dual ligand system employing a bisphosphine and bisphosphine monoxide was used to achieve enantioenriched products.
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