清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial

医学 马车 抗生素 内科学 随机对照试验 耐碳青霉烯类肠杆菌科 粪便 移植 多重耐药 肠杆菌科感染 肠杆菌科 微生物学 生物 病理 基因 大肠杆菌 生物化学
作者
Benedikt Huttner,Victoire de Lastours,M.W.M. Wassenberg,Nitsan Maharshak,A. Mauris,Tatiana Galpérine,Veronica Zanichelli,Nathalie Kapel,Agnès Bellanger,Flaminia Olearo,Xavier Duval,Laurence Armand-Lefèvre,Yehuda Carmeli,Marc J. M. Bonten,B. Fantin,Stephan Harbarth,Livia Colle,F. Kloosterman,Wilma van Bentum-Puijk,Judith Vlooswijk
出处
期刊:Clinical Microbiology and Infection [Elsevier BV]
卷期号:25 (7): 830-838 被引量:146
标识
DOI:10.1016/j.cmi.2018.12.009
摘要

ObjectivesIntestinal carriage with extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) can persist for months. We aimed to evaluate whether oral antibiotics followed by faecal microbiota transplantation (FMT) can eradicate intestinal carriage with ESBL-E/CPE.MethodsRandomized, open-label, superiority trial in four tertiary-care centres (Geneva (G), Paris (P), Utrecht (U), Tel Aviv (T)). Non-immunocompromised adult patients were randomized 1: 1 to either no intervention (control) or a 5-day course of oral antibiotics (colistin sulphate 2 × 106 IU 4×/day; neomycin sulphate 500 mg 4×/day) followed by frozen FMT obtained from unrelated healthy donors. The primary outcome was detectable intestinal carriage of ESBL-E/CPE by stool culture 35–48 days after randomization (V4). ClinicalTrials.govNCT02472600. The trial was funded by the European Commission (FP7).ResultsThirty-nine patients (G = 14; P = 16; U = 7; T = 2) colonized by ESBL-E (n = 36) and/or CPE (n = 11) were enrolled between February 2016 and June 2017. In the intention-to-treat analysis 9/22 (41%) patients assigned to the intervention arm were negative for ESBL-E/CPE at V4 (1/22 not receiving the intervention imputed as positive) whereas in the control arm 5/17 (29%) patients were negative (one lost to follow up imputed as negative) resulting in an OR for decolonization success of 1.7 (95% CI 0.4–6.4). Study drugs were well tolerated overall but three patients in the intervention group prematurely stopped the study antibiotics because of diarrhoea (all received FMT).ConclusionsNon-absorbable antibiotics followed by FMT slightly decreased ESBL-E/CPE carriage compared with controls; this difference was not statistically significant, potentially due to early trial termination. Further clinical investigations seem warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wenbinvan完成签到,获得积分0
16秒前
GIA完成签到,获得积分10
22秒前
Djnsbj发布了新的文献求助10
32秒前
32秒前
mia发布了新的文献求助10
38秒前
爱静静应助Benhnhk21采纳,获得10
38秒前
Djnsbj关注了科研通微信公众号
1分钟前
KINGAZX完成签到 ,获得积分10
1分钟前
桐桐应助泥巴采纳,获得10
1分钟前
jackone完成签到,获得积分10
1分钟前
2分钟前
mia完成签到,获得积分10
2分钟前
2分钟前
2分钟前
3分钟前
3分钟前
科研通AI2S应助科研通管家采纳,获得20
3分钟前
可爱的函函应助安琦采纳,获得10
3分钟前
3分钟前
minjeong完成签到,获得积分10
3分钟前
3分钟前
4分钟前
LRxxx完成签到 ,获得积分10
4分钟前
白菜完成签到 ,获得积分10
4分钟前
4分钟前
4分钟前
4分钟前
5分钟前
5分钟前
泥巴发布了新的文献求助10
5分钟前
5分钟前
安琦发布了新的文献求助10
5分钟前
111完成签到 ,获得积分10
5分钟前
5分钟前
5分钟前
机智咖啡豆完成签到 ,获得积分10
5分钟前
6分钟前
自强不息完成签到 ,获得积分10
6分钟前
6分钟前
6分钟前
高分求助中
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
Peking Blues // Liao San 300
Political Ideologies Their Origins and Impact 13 edition 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3800936
求助须知:如何正确求助?哪些是违规求助? 3346489
关于积分的说明 10329439
捐赠科研通 3063031
什么是DOI,文献DOI怎么找? 1681317
邀请新用户注册赠送积分活动 807463
科研通“疑难数据库(出版商)”最低求助积分说明 763714