催化作用
醛
反应性(心理学)
瞬态(计算机编程)
小学(天文学)
化学
配体(生物化学)
选择性
活动站点
组合化学
有机化学
计算机科学
生物化学
受体
物理
病理
操作系统
替代医学
医学
天文
作者
Yi-Hao Li,Yuxin Ouyang,Nikita Chekshin,Jin‐Quan Yu
标识
DOI:10.26434/chemrxiv-2022-bt3z4
摘要
Pd(II)-catalyzed site-selective β- and γ-C(sp3)−H arylation of primary aldehydes is developed by rational design of L,X-type transient directing groups (TDG). External 2-pyridone ligands are identified to be crucial for the observed reactivity. By minimizing the loading of acid additives, the ligand effect is enhanced to achieve high reactivities of the challenging primary aldehyde substrates. Site-selectivity can be switched from the proximate to the relatively remote position by changing the bite angle of TDG to match the desired palladacycle size. Experimental and computational investigations support this rationale for designing TDG to potentially achieve remote site-selective C(sp3)−H functionalizations.
科研通智能强力驱动
Strongly Powered by AbleSci AI