生物膜
铜绿假单胞菌
微生物学
细菌
生物
基质(化学分析)
多糖
化学
生物化学
遗传学
色谱法
作者
Luyan Zhang,Di Wang,Yiwei Liu,Zhenyu Zhang,Daniel J. Wozniak
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2022-09-08
卷期号:76 (1): 413-433
被引量:35
标识
DOI:10.1146/annurev-micro-041320-111355
摘要
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms. Here, we focus on biofilm matrix exopolysaccharides in Pseudomonas aeruginosa. This opportunistic pathogen can adapt to a wide range of environments and can form biofilms or aggregates in a variety of surfaces or environments, such as the lungs of people with cystic fibrosis, catheters, wounds, and contact lenses. The ability to synthesize multiple exopolysaccharides is one of the advantages that facilitate bacterial survival in different environments. P. aeruginosa can produce several exopolysaccharides, including alginate, Psl, Pel, and lipopolysaccharide. In this review, we highlight the roles of each exopolysaccharide in P. aeruginosa biofilm development and how bacteria coordinate the biosynthesis of multiple exopolysaccharides and bacterial motility. In addition, we present advances in antibiofilm strategies targeting matrix exopolysaccharides, with a focus on glycoside hydrolases.
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