自噬
溶酶体
肿瘤微环境
背景(考古学)
癌细胞
细胞生物学
生物
嘌呤能受体
分泌物
信号
癌症
免疫系统
作者
Samantha Barbonari,Antonella D'Amore,Fioretta Palombi,Paola De Cesaris,John Parrington,Anna Riccioli,Antonio Filippini
出处
期刊:Cell Calcium
[Elsevier]
日期:2022-01-01
卷期号:: 102539-102539
标识
DOI:10.1016/j.ceca.2022.102539
摘要
In comparison with normal cells, cancer cells are equipped with a higher number of lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is a Ca2+signalling hub, and the enhancement of this interconnected machinery in cancer cells has recently prompted investigations into the role that lysosomal ion channels play in oncology. The present review reports findings about the emerging role of lysosomal Ca2+channels: Two-Pore Channels (TPCs), Transient Receptor Potential Cation Channels (TRPMLs; mucolipins), and Purinergic X Receptor 4 (P2×4R), in a variety of cancer models, highlighting their impact on crucial functions such as the regulation of autophagy and the composition of the tumour microenvironment, including the secretion-mediated interplay with immune and endothelial cells. Notably, recent evidence indicates that, by regulating tumour secretome, lysosomal Ca2+ signalling can affect the composition of the tumour-infiltrating immune cell repertoire. Intriguingly, the data so far available show that the protumoral/antitumoral role of lysosomal Ca2+ channels can differ according to the specific genetic context, types of cancer and the malignancy stage, and signals from the microenvironment.
科研通智能强力驱动
Strongly Powered by AbleSci AI