抗菌剂
杀生物剂
自愈水凝胶
纳米技术
生物膜
抗生素耐药性
抗感染药
聚合物
抗菌肽
抗菌药物
化学
材料科学
微生物学
抗生素
生物
细菌
有机化学
遗传学
作者
Mohini M. Konai,Brinta Bhattacharjee,Sreyan Ghosh,Jayanta Haldar
出处
期刊:Biomacromolecules
[American Chemical Society]
日期:2018-05-02
卷期号:19 (6): 1888-1917
被引量:210
标识
DOI:10.1021/acs.biomac.8b00458
摘要
Global health is increasingly being threatened by the rapid emergence of drug-resistant microbes. The ability of these microbes to form biofilms has further exacerbated the scenario leading to notorious infections that are almost impossible to treat. For addressing this clinical threat, various antimicrobial polymers, polymer-based antimicrobial hydrogels and polymer-coated antimicrobial surfaces have been developed in the recent past. This review aims to discuss such polymer-based antimicrobial strategies with a focus on their current advancement in the field. Antimicrobial polymers, whose designs are inspired from antimicrobial peptides (AMPs), are described with an emphasis on structure-activity analysis. Additionally, antibiofilm activity and in vivo efficacy are delineated to elucidate the real potential of these antimicrobial polymers as possible therapeutics. Antimicrobial hydrogels, prepared from either inherently antimicrobial polymers or biocide-loaded into polymer-derived hydrogel matrix, are elaborated followed by various strategies to engineer polymer-coated antimicrobial surfaces. In the end, the current challenges are accentuated along with future directions for further expansion of the field toward tackling infections and antimicrobial resistance.
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