医学
环磷酰胺
转移
免疫疗法
联合疗法
癌症研究
豇豆花叶病毒
体内
免疫抑制
化疗
癌症
乳腺癌
原发性肿瘤
三阴性乳腺癌
肿瘤科
免疫学
内科学
病毒
生物
生物技术
植物病毒
作者
Hui Cai,Chao Wang,Sourabh Shukla,Nicole F. Steinmetz
标识
DOI:10.1002/advs.201802281
摘要
Abstract Patients with metastatic triple‐negative breast cancer (TNBC) have a poor prognosis, so new therapies or drug combinations that achieve more effective and durable responses are urgently needed. Here, a combination therapy using cowpea mosaic virus (CPMV) and low doses of cyclophosphamide (CPA) is developed with remarkable synergistic efficacy against 4T1 mouse tumors in vivo. The combination therapy not only attenuates the growth of primary tumor and increases survival, but also suppresses distant tumor growth and reduces lung metastasis. Mechanistic analysis indicates that the combination of CPMV and CPA increases the secretion of several cytokines, activates antigen‐presenting cells, increases the abundance of tumor infiltrating T cells, and systematically reverses the immunosuppression. These results show that the combination of CPMV in situ vaccination with chemotherapy may become a potent new strategy for the treatment of TNBC.
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