化学
吡啶
衍生工具(金融)
立体化学
戒指(化学)
选择性
组合化学
药物化学
有机化学
催化作用
金融经济学
经济
作者
H. R. Sharma,Archana Gupta,Reshma Kumari,May Lee Low,Wie Meng Lim,Marilyn Daisy Milton
标识
DOI:10.1002/slct.202300873
摘要
Abstract A series of substituted 1 ‐azaphenothiazine was synthesized by Smiles rearrangement and was further used to synthesize 10 ‐( 2 ′‐morpholinylethyl) derivatives. All compounds were characterized by various specroscopic techniques. One derivative from each series was also characterized by single crystal X‐ray diffraction (SCXRD) method. Compounds of both series were screened for their anticancer activity toward colon (CaCO2, SW48), lung (A549), pancreatic (SW1990) and human breast (MDA‐MB‐231, MCF‐7) cancer cell lines. 10 ‐( 2 ′‐Morpholinylethyl)‐ 1 ‐azaphenothiazine derivatives were found to be more potent than that of 1 ‐azaphenothiazine derivatives toward anticancer activities. Among all compounds, one of the morpholinylethyl derivative which is substituted with chlorine at 3‐ position of pyridine ring, exhibits better selectivity toward both colon cancer (SW48) and breast cancer cells (MCF7).
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