前药
材料科学
纳米颗粒
胶质瘤
二极管
对偶(语法数字)
纳米技术
光电子学
癌症研究
医学
药理学
艺术
文学类
作者
Jung-Suk Goo,Jun Seo Lee,Junwon Park,Seong Ik Jeon,Jeongrae Kim,Wan Su Yun,Nayeon Shim,Yujeong Moon,Sunejeong Song,Jinseong Kim,Hanhee Cho,Ju Yeon Jeong,Ju Seung Lee,Sangheon Han,Hyeon-Ju Lee,Won‐Gun Koh,Won Seok Chang,Tae‐il Kim,Kwangmeyung Kim
出处
期刊:ACS Nano
[American Chemical Society]
日期:2025-04-28
被引量:1
标识
DOI:10.1021/acsnano.4c17421
摘要
Glioma is a highly lethal tumor with a poor prognosis, in which the presence of the blood-brain barrier (BBB) and skull significantly limits treatment options. To address this, a tumor-implantable optofluidic system (LED-SC), consisting of a microsized LED (microLED) and a microsyringe chip (SC), is proposed to deliver both light and prodrug nanoparticles (PNPs) directly to brain glioma. The LED-SC combines microLED and SC to enable intratumoral administration of light and PNPs for chemophotodynamic therapy. PNPs, self-assembled nanoparticles of verteporfin (VPF)-doxorubicin (DOX) prodrug, are cleaved by the enzyme cathepsin B, releasing active drugs specifically within tumor cells. In vitro studies show that PNPs are taken up by glioma cells and exhibit enhanced cytotoxicity under light irradiation. The PNPs-loaded LED-SC can be implanted into glioma, wherein PNPs are slowly diffused through the tumor, bypassing the BBB, and it also ensures effective light delivery in glioma beneath the skull, boosting chemo-photodynamic therapy. In glioma mouse models, PNP-loaded LED-SC implantation showed a 3.9-fold improvement in PNP delivery efficiency over intravenous administration, leading to better drug distribution and therapeutic results. The PNPs-loaded LED-SC offers a promising and minimally invasive solution for glioma treatment, overcoming the barriers of the BBB and skull while reducing systemic toxicity.
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