斑马鱼
微塑料
达尼奥
邻苯二甲酸盐
发育毒性
氧化应激
孵化
化学
活性氧
生态毒理学
污染物
生物
环境化学
毒理
生物化学
生态学
怀孕
妊娠期
遗传学
有机化学
基因
作者
Hongdan Wang,Yunqing Wang,Qiaoning Wang,Min Lv,Xizhen Zhao,Yaying Ji,Xiaoyue Han,Xiaoyan Wang,Lingxin Chen
标识
DOI:10.1016/j.jhazmat.2022.129711
摘要
Microplastics (MPs) have the characteristics of large specific surface area, high hydrophobicity and surface charge, so they are easy to combine with other pollutants and cause toxic effects on aquatic organisms. Here, we prepared a polyvinyl chloride-microplastics (PVC-MPs) fragmentation model to simulate the real microplastic state, and characterized its composition, morphology, particle size and zeta potential. On this basis, we used single and compound exposure of PVC and di(2-ethylhexyl) phthalate (DEHP) to explore their effects on hatchability and mortality of zebrafish (Danio rerio) embryos and toxicity to oxidative stress and cardiac development in zebrafish larvae. Herein, PVC-MPs slowed down the hatching rate of zebrafish embryos and induced the death of zebrafish, while DEHP could slow down the induced of death, it had no effect on hatching rate. The PVC-MPs/DEHP single pollution could induce the reactive oxygen species (ROS) and activated the antioxidant defense signaling pathway, while the compound group showed the level of feedback autoregulation of NF-E2-related factor 2 (Nrf2) signaling pathway. The single pollution also could inhibit the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect. This study provided a theoretical basis for the ecotoxicology and biomonitoring of MPs in the natural state.
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