细菌
化学
抗菌剂
聚集诱导发射
活性氧
金黄色葡萄球菌
细胞内
多重耐药
抗菌活性
荧光
组合化学
微生物学
生物物理学
抗生素
生物化学
生物
有机化学
物理
量子力学
遗传学
作者
Yifan Wu,Jiangao Li,Zipeng Shen,DeLiang Wang,Ruihua Dong,Jiangjiang Zhang,Yinzhen Pan,Ying Li,Dong Wang,Ben Zhong Tang
标识
DOI:10.1002/anie.202212386
摘要
Novel antibacterial agents are urgently needed to control the infections induced by multidrug-resistant (MDR) bacteria. Herein, we rationally designed and facilely synthesized a new D-π-A type luminogen with strong red/near-infrared fluorescence emission, great aggregation-induced emission (AIE) features, and excellent reactive oxygen species (ROS) production. The newly developed molecule TTTh killed the methicillin-resistant Staphylococcus aureus (MRSA) by triggering the ROS accumulation in bacteria and interrupting the membrane integrity. Moreover, TTTh specifically targeted the lysosomes and potentiated their maturation to accelerate the clearance of intracellular bacteria. Additionally, reduced bacterial burden and improved healing were observed in TTTh-treated wounds with negligible side effects. Our study expands the biological design and application of AIE luminogens (AIEgens), and provides new insights into discovering novel antibacterial targets and agents.
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