两性霉素B
白色念珠菌
卡斯波芬金
光滑假丝酵母
医学
假丝酵母病
克鲁斯假丝酵母
伊曲康唑
热带假丝酵母
米卡芬金
茴香菌素
抗真菌药
抗药性
真菌血症
作者
Meng Xiao,Sharon C.-A. Chen,Fanrong Kong,Xiu-Li Xu,Li Yan,Haishen Kong,Xin Fan,Xin Hou,Jing-Wei Cheng,Menglan Zhou,Ying Li,Shu-Ying Yu,Jing-Jing Huang,Ge Zhang,Yang Yang,Jingjia Zhang,Simeng Duan,Wei Kang,He Wang,Yingchun Xu
标识
DOI:10.1093/infdis/jiz573
摘要
BACKGROUND Candidemia is the most common, serious fungal infection and Candida antifungal resistance is a challenge. We report recent surveillance of candidemia in China. METHODS The study encompassed 77 Chinese hospitals over 3 years. Identification of Candida species was by mass spectrometry and DNA sequencing. Antifungal susceptibility was determined using the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS In total, 4010 isolates were collected from candidemia patients. Although C. albicans was the most common species, non-albicans Candida species accounted for over two-thirds of isolates, predominated C. parapsilosis complex (27.1%), C. tropicalis (18.7%), and C. glabrata complex (12.0%). Most C. albicans and C. parapsilosis complex isolates were susceptible to all antifungal agents (resistance rate 56% of C. haemulonii isolates were multidrug resistance. CONCLUSIONS Non-albicans Candida species are the predominant cause of candidemia in China. Azole resistance is notable amongst C. tropicalis and C. glabrata. Coresistance and multidrug resistance has emerged in less common Candida species.
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