介孔二氧化硅
纳米载体
生物降解
盐酸阿霉素
材料科学
纳米颗粒
癌细胞
阿霉素
氧化还原
组合化学
癌症治疗
纳米技术
生物物理学
化学
介孔材料
有机化学
癌症
化疗
催化作用
医学
外科
内科学
生物
作者
Yongju He,Linjie Shao,Yao Hu,Fuwen Zhao,Songwen Tan,Dan He,Anqiang Pan
标识
DOI:10.1016/j.ceramint.2020.10.022
摘要
Multifunctional mesoporous silica-based nanocarriers able to efficiently encapsulate drugs for stimuli-responsive release and display rapid biodegradation are highly desirable. In this work, we dope disulfide bonds and calcium into silica framework by one step method to obtain a redox and pH dual-responsive biodegradable mesoporous silica nanoparticle (BT-Ca-MSN) as a potential drug carrier for synergistic cancer therapy. TEM and ICP-OES are used to assess the biodegradation behavior of BT-Ca-MSN. The results show that BT-Ca-MSN can significantly biodegrade in a concurrent reductive and acidic environment due to the simultaneous disulfide bonds cleavage and Ca2+ release. In addition, BT-Ca-MSN shows efficient drug loading capacity and significant biodegradation-mediated drug release. Moreover, the in-vitro cytotoxicity indicates that BT-Ca-MSN can not only exhibit significant cancer cell killing effect without obvious toxicity on healthy cells via the way of released Ca2+-mediated apoptosis, but also can combine with its loaded doxorubicin hydrochloride for synergistic cancer therapy. This work demonstrates that BT-Ca-MSN is a promising platform as drug carrier, providing a paradigm to rationally design biodegradable silica-based carriers for highly efficient cancer therapy.
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