An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

(Cell 163, 381–393; October 8, 2015) Upon reviewing the Supplemental Experimental Procedures in the above articles, the authors found three errors in measurements. In the section titled “Confirmation of SFB Colonization,” “100 ng/ml” should have been “100 μg/ml.” In the section titled “Isolation of Lamina Propria Lymphocytes and Epithelial Cells,” “50 U/ml” should have been “0.1 U/ml.” And in the section titled “SFB-specific Transgenic T Cell Transfer,” “500 ng/ml” should have been “50 ng/ml.” These measurements have been corrected online. In addition, we have removed the phrase “relative gene expression” from the figure legends for Figures 1D, 6B, and S4. In those figures, the orange bar represents the average for each group, not the average relative gene expression. We sincerely regret these errors and apologize for any inconvenience they may have caused. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 ResponsesSano et al.CellSeptember 24, 2015In BriefCytokines produced by Th17 cells are critical for protection and repair of mucosal barriers. IL-17A production is orchestrated by localization of specific poised Th17 cells at sites where the gut microbiome drives epithelial secretion of serum amyloid A. Full-Text PDF Open Archive