生物污染
自愈水凝胶
材料科学
聚乙二醇
生物膜
PEG比率
儿茶酚
自愈
抗菌剂
粘附
共聚物
纳米技术
化学工程
高分子化学
有机化学
化学
聚合物
生物化学
复合材料
细菌
经济
病理
生物
工程类
膜
替代医学
医学
财务
遗传学
作者
Lin Li,Bin Yan,Jianguo Yang,Weijuan Huang,Lingyun Chen,Hongbo Zeng
标识
DOI:10.1021/acsami.6b16192
摘要
Microbial adhesion, biofilm formation and associated microbial infection are common challenges faced by implanted biomaterials (e.g., hydrogels) in bioengineering applications. In this work, an injectable self-healing hydrogel with antimicrobial and antifouling properties was prepared through self-assembly of an ABA triblock copolymer employing catechol functionalized polyethylene glycol (PEG) as A block and poly{[2-(methacryloyloxy)-ethyl] trimethylammonium iodide}(PMETA) as B block. This hydrogel exhibits excellent thermosensitivity, and can effectively inhibit the growth of E. coli (>99.8% killing efficiency) and prevent cell attachment. It can also heal autonomously from repeated damage, through mussel-inspired catechol-mediated hydrogen bonding and aromatic interactions, exhibiting great potential in bioengineering applications.
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