不分离
减数分裂
非整倍体
生物
三体
生殖细胞
胚胎
联会复合体
遗传学
核型
染色体
基因
作者
Yuan Li,Jianguo Liu,Mary-Rose Hoja,Johannes Wilbertz,Katarina Nordqvist,Christer Höög
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2002-05-10
卷期号:296 (5570): 1115-1118
被引量:320
标识
DOI:10.1126/science.1070594
摘要
Aneuploidy (trisomy or monosomy) is the leading genetic cause of pregnancy loss in humans and results from errors in meiotic chromosome segregation. Here, we show that the absence of synaptonemal complex protein 3 (SCP3) promotes aneuploidy in murine oocytes by inducing defective meiotic chromosome segregation. The abnormal oocyte karyotype is inherited by embryos, which die in utero at an early stage of development. In addition, embryo death in SCP3-deficient females increases with advancing maternal age. We found that SCP3 is required for chiasmata formation and for the structural integrity of meiotic chromosomes, suggesting that altered chromosomal structure triggers nondisjunction. SCP3 is thus linked to inherited aneuploidy in female germ cells and provides a model system for studying age-dependent degeneration in oocytes.
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