芬太尼
柠檬酸
组合化学
盐酸盐
化学
药理学
有机化学
医学
作者
Carlos A. Valdez,Roald N. Leif,Brian Mayer
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2014-09-18
卷期号:9 (9): e108250-e108250
被引量:62
标识
DOI:10.1371/journal.pone.0108250
摘要
The alternate and optimized syntheses of the parent opioid fentanyl and its analogs are described. The routes presented exhibit high-yielding transformations leading to these powerful analgesics after optimization studies were carried out for each synthetic step. The general three-step strategy produced a panel of four fentanyls in excellent yields (73-78%) along with their more commonly encountered hydrochloride and citric acid salts. The following strategy offers the opportunity for the gram-scale, efficient production of this interesting class of opioid alkaloids.
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