马链球菌
抗原
接种疫苗
佐剂
马
微生物学
病毒学
免疫学
医学
呼吸道
生物
呼吸系统
细菌
内科学
遗传学
古生物学
作者
Andrew S. Waller,Margareta Flock,Ken Smith,Carl Robinson,Zoe Mitchell,Åsa Karlström,Jonas Lannergård,R. Bergman,Bengt Guss,Jan‐Ingmar Flock
出处
期刊:Vaccine
[Elsevier]
日期:2007-05-01
卷期号:25 (18): 3629-3635
被引量:32
标识
DOI:10.1016/j.vaccine.2007.01.060
摘要
Strangles is an upper respiratory tract infection in horses, which is highly contagious and one of the more costly diseases of the horse. Three recombinant antigens were used to vaccinate horses, which were then experimentally challenged with Streptococcus equi, the causative agent for strangles. The vaccinated horses showed significantly reduced bacterial growth (p=0.02) and nasal discharge (p=0.0004), a typical symptom of strangles. Other clinical signs of strangles were also reduced and at post mortem examination, lower rate of empyaema or scarring of the guttural pouches was found in the vaccinated group (p=0.01). The antigens used were EAG (alpha2-macroglobulin, albumin, and IgG-binding protein), CNE (a collagen-binding protein), and SclC (a collagen-like protein). The adjuvant used was Abisco, a saponin derived matrix. No adverse effects were observed following vaccination with the antigens and adjuvant.
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