材料科学
纳米复合材料
自愈水凝胶
弹性体
明胶
生物医学工程
组织工程
生物材料
再生(生物学)
生物相容性
复合材料
光致聚合物
伤口愈合
高分子化学
化学
有机化学
医学
细胞生物学
生物
作者
Teena Thakur,Janet R. Xavier,Lauren Cross,Manish K. Jaiswal,Eli Mondragón,Roland Kaunas,Akhilesh K. Gaharwar
摘要
Abstract Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 879–888, 2016.
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