医学
荟萃分析
微量白蛋白尿
蛋白尿
内科学
置信区间
出版偏见
糖尿病肾病
糖尿病
C反应蛋白
肾病
尿
胃肠病学
内分泌学
炎症
作者
Liu Q,Jiang Cy,Chen Bx,Wen-Man Zhao,Dan Meng
出处
期刊:PubMed
日期:2015-12-01
卷期号:19 (23): 4558-68
被引量:11
摘要
To explore the association between high-sensitivity C-reactive protein (hs-CRP) concentration and diabetic nephropathy (DN).We systematically searched Pubmed, Medline and Embase databases up to September, 2014 for the relevant studies. Heterogeneity across studies was evaluated by Cochran's Q test and I2 statistic. The standard mean difference (SMD) and the corresponding 95% confidence interval (CI) were combined to evaluate the effect size. Sensitivity analysis was also performed by omitting each study to evaluate the stability of the results. In addition, publication bias was tested by Egger's test.A total of 11 studies containing 1 331 cases and 1 779 controls were included in this study. Significant heterogeneities were observed in our results. The result of meta-analysis showed that the hs-CRP concentrations in DN patients were significantly higher than that in controls of healthy people and diabetes mellitus (DM) patients without nephropathy. In addition, the hs-CRP concentration in macroalbuminuria (D3) group was significantly higher than that in microalbuminuria (D2) group and non-albuminuria group (D1). Sensitivity analysis revealed that the results were stable. As well, no publication bias was observed in our results.We suggest that hs-CRP concentration can be an indicator of DN in DM patients.
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