Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress

内分泌学 内科学 牛磺酸 代谢组 代谢物 化学 炎症 尿 渗透调节 排泄 生物 医学 生物化学 氨基酸 盐度 生态学
作者
Tatsuhiko Goto,Yoshifumi Kubota,Atsushi Toyoda
出处
期刊:Journal of Proteome Research [American Chemical Society]
卷期号:14 (2): 1025-1032 被引量:27
标识
DOI:10.1021/pr501044k
摘要

To improve the quality of life of animals, understanding of stress-induced changes is necessary. Previously, we established a subchronic and mild social defeat stress (sCSDS) model in mice, which showed significantly higher body weight gain, food intake, and water intake compared to control mice. In this study, we elucidated metabolic profiles of plasma, liver, and urine in sCSDS mice by using metabolome and biochemical analyses. There was no significant difference between defeated and control mice in the plasma metabolites. In the liver of sCSDS mice, levels of taurocyamine (GES), phosphorylcholine, D-alanyl-D-alanine (D-ala-D-ala), and 1-methylnicotinamide (MNA) were elevated compared to controls. Taurine plays a role in osmotic regulation, and GES is a potential inhibitor of the taurine transporter. The polydipsia and increased body water content in sCSDS mice may disrupt body fluid balance following GES elevation. Furthermore, sCSDS increased heart and spleen weight significantly. Because MNA and D-ala-D-ala have anti-inflammatory and hepatoprotective effects, they may reduce inflammation in the liver of sCSDS mice. Finally, suppressed excretion of urine sodium was observed in sCSDS mice. Therefore, sCSDS induces various changes in metabolite concentrations, especially related to osmoregulation and inflammation, that may be used as biomarkers for stress-induced changes in animals.
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