医学
蛛网膜下腔出血
病理生理学
血管痉挛
病因学
脑血管痉挛
缺血
脑灌注压
颅内压
动脉瘤
重症监护医学
心脏病学
内科学
脑血流
麻醉
外科
作者
Simge Yuksel,Yusuf Berk Tosun,Julian Cahill,Ihsan Solaroglu
出处
期刊:Turkish Neurosurgery
[Turkish Neurosurgical Society]
日期:2012-01-01
被引量:30
标识
DOI:10.5137/1019-5149.jtn.5731-12.1
摘要
Subarachnoid hemorrhage (SAH) due to intracranial aneurysm rupture is a complex clinical disease with high mortality and morbidity. Recent studies suggest that early brain injury (EBI) rather than vasospasm might be responsible for morbidity and mortality within 24-72 hours after SAH. The rise in intracranial pressure following SAH causes a significant drop in cerebral perfusion pressure that leads to global cerebral ischemia and initiates the acute injury cascade. Various molecular mechanisms have been shown to involve in the pathophysiology of EBI including cellular apoptosis. In this review, we summarize apoptotic molecular mechanisms involved in the etiology of EBI and its potential as a target for future therapeutic intervention.
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