ITLN1 Improves Endothelial Dysfunction in Hypertensive Mice via Wnt5b-JNK Signaling

This study identified ITLN1 as a potential therapeutic target for hypertension. Upregulating ITLN1 protected against endothelial dysfunction by modulating Wnt5b-JNK/endothelial nitric oxide synthase signaling, with puerarin 6-O-xyloside serving as a promising ITLN1 activator.