纳米医学
生物相容性
纳米技术
体外
体内
化学
纳米颗粒
细胞
生物物理学
细胞生物学
材料科学
生物
生物化学
生物技术
有机化学
作者
Liang Zhen,Yang He,Christina SU Ieong,Chung Hang Jonathan Choi
标识
DOI:10.1016/j.copbio.2023.103013
摘要
Polydopamine (PDA) nanoparticles (NPs) have diverse nanomedicine applications owing to their biocompatibility and abundant entry to cells. Yet, our knowledge in their interactions with cells was infrequently studied until recent years. This review presents the latest insights into the cell-nano interactions of PDA NPs, including their 'self-targeting' to dopamine receptors for cellular entry without the aid of ligands, in vitro 'self-therapeutic' cellular responses (antiferroptosis, macrophage polarization, and modulation of mitochondrial bioenergetics) in the absence of drugs, and in vivo cellular localization and pharmacological properties upon various routes of administration. This review concludes with our perspectives on the therapeutic promise of PDA NPs and the need for studies on PDA biochemistry, biodegradability, and protein adsorption.
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