迷迭香
支气管肺泡灌洗
医学
丹参
药理学
哮喘
氧化应激
抗氧化剂
炎症
卵清蛋白
肺
TBARS公司
免疫学
传统医学
官房
内科学
化学
脂质过氧化
病理
免疫系统
生物化学
中医药
替代医学
作者
Mohammad Amin Rajizadeh,Mohammad Abbas Bejeshk,Amirhashem Aminizadeh,Abolfazl Yari,Fahimeh Rostamabadi,Fariborz Bagheri,Hamid Najafipour,Mohammad Hadi Nematollahi,Arian Amirkhosravi,Mehrnaz Mehrabani,Mehrnaz Mehrabani
出处
期刊:Pharmacology
[S. Karger AG]
日期:2023-11-02
卷期号:: 1-12
被引量:1
摘要
For centuries, Salvia rosmarinus Spenn has been applied as folk medicine to cure different diseases due to its anti-inflammatory, antibacterial, antioxidant, antifungal, and antitumor effects. To find bioactive medicinal herbs exerting a protective effect on airway inflammation and remodeling, we assessed the anti-oxidative and anti-inflammatory effects of an aqueous spray-dried extract of Salvia rosmarinus Spenn. (rosemary) in an ovalbumin-induced asthmatic rat model.Rats were randomly divided into normal control (control), asthma, asthma+rosemary extract (RE) (13 mg/kg), asthma+RE (50 mg/kg), and asthma+budesonide groups. After 50 days, animals were anesthetized, and then blood, bronchoalveolar lavage fluid (BALF), and lung tissues were collected for subsequent serological and pathological studies. Histopathology of lung tissues was evaluated by H&E staining. The oxidative stress parameters and airway inflammation factors in BALF and lung tissue were explored.Using thin layer chromatography, the presence of rosmarinic acid was confirmed in aqueous extract of rosemary. Furthermore, RE markedly decreased immunoglobulin E levels (50 mg/kg; p < 0.001 vs. asthma group) and inflammatory cytokines (50 mg/kg; p < 0.001 vs. asthma group) and increased antioxidant enzymes (50 mg/kg, p < 0.001 vs. asthma group). Furthermore, RE at a concentration of 50 mg/kg obviously reduced the number of inflammatory cells, goblet cells, and pathological changes compared to the asthma group.The results showed that RE administration might prevent or alleviate allergic asthma-related pathological change, probably via antioxidant and anti-inflammatory mechanisms.
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