中缝背核
神经炎症
化学
海马体
扁桃形结构
小胶质细胞
神经科学
内科学
扩大杏仁核
核心
血清素
内分泌学
5-羟色胺能
心理学
炎症
受体
生物
终纹
医学
生物化学
作者
Chunyan Zhu,Xuemin Yao,Dandan Liu,Guoxin Zhang,Yongping Zhu,Hongyu Chi,S. Zhang,Jun Yang,Ying Liu,Jigang Wang,Na Lin
标识
DOI:10.1016/j.jpha.2023.10.002
摘要
• The expression of PDIA3 is differentially disturbed in the BLA, CA3 and DRN of the obesity-depression comorbid mice. • Celastrol covalently bind and differentially modulate the expression of PDIA3 in above brain nuclei. • PDIA3 expressed in BLA and CA3 alleviate the comorbid conditions, whereas in DRN deteriorate obesity. • In BLA and CA3, overexpressed PDIA3 reshape the activated amoeboid microglia into the ramified quiescent ones. • In DRN, overexpressed PDIA3 may influence 5-HTergic neurons.
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