Bidirectional Effect of Triphala on Modulating Gut‐Brain Axis to Improve Cognition in the Murine Model of Alzheimer's Disease

Scope The emerging role of gut microbiota and their metabolites in the modulation of the gut‐brain axis has received much attention as a new hope for the treatment of hard‐to‐treat chronic neurodegenerative diseases like Alzheimer's disease. The naturally occurring polyphenols can restore the gut‐brain axis by modulating gut microbiota and brain neurotransmitters. The Indian traditional medicine Triphala, a rich source of polyphenols, has been used on humans based on Prakriti or disease conditions for many years. Methods and results In this study, the dual mode (morning and evening) action of Triphala is used to provide scientific evidence of its superior preventive and therapeutic efficacy in C57BL/6 and 5xFAD, APP/PS1 transgenic mouse model of Alzheimer's disease. The study observes that Triphala treatment has significantly improved cognitive function, by modulating the APP pathway, reducing inflammation, and restoring the gut‐brain axis by increasing the gut microbiota phyla of Bacteroides, Proteobacteria, Actinobacteria, etc., involved in maintaining the gut homeostasis. Conclusions The study paves a new path for using dual modes of Triphala alone or in combination to treat incurable AD.