特应性皮炎
生物医学工程
银屑病
医学
高分辨率
计算机科学
皮肤病科
遥感
地质学
作者
Surabhi R. Madhvapathy,Heling Wang,Jessy Kong,Michael Z. Zhang,Jong Yoon Lee,Jun Bin Park,Hokyung Jang,Zhaoqian Xie,Jingyue Cao,Raudel Avila,Wei Chen,Vincent E D'Angelo,Jason Zhu,Ha Uk Chung,Sarah Coughlin,Manish Patel,Joshua Winograd,Jaeman Lim,Anthony Banks,Shuai Xu,Yonggang Huang,Jinghua Li
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2020-12-04
卷期号:6 (49)
被引量:36
标识
DOI:10.1126/sciadv.abd7146
摘要
Present-day dermatological diagnostic tools are expensive, time-consuming, require substantial operational expertise, and typically probe only the superficial layers of skin (~15 μm). We introduce a soft, battery-free, noninvasive, reusable skin hydration sensor (SHS) adherable to most of the body surface. The platform measures volumetric water content (up to ~1 mm in depth) and wirelessly transmits data to any near-field communication-compatible smartphone. The SHS is readily manufacturable, comprises unique powering and encapsulation strategies, and achieves high measurement precision (±5% volumetric water content) and resolution (±0.015°C skin surface temperature). Validation on n = 16 healthy/normal human participants reveals an average skin water content of ~63% across multiple body locations. Pilot studies on patients with atopic dermatitis (AD), psoriasis, urticaria, xerosis cutis, and rosacea highlight the diagnostic capability of the SHS (PAD = 0.0034) and its ability to study impact of topical treatments on skin diseases.
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