Potential application development of Sr/HCOOH metal organic framework in osteoarthritis

Metal Organic Frameworks (MOFs) are widely used in various engineering applications, including energy storage, chemical catalysis, etc. However, their potential functions in disease therapy, especially alkaline-earth based MOFs, still need to be developed. In this study, Sr/HCOOH-MOF is successfully prepared and characterized by using XRD, FTIR, TGA, SEM and BET. Drug loading and releasing experiments proved that only 3% ketoprofen was loaded on the Sr/HCOOH-MOF and approximately 80% ketoprofen was released from it after 8 h. Moreover, the potential application of Sr/HCOOH-MOF on attenuating osteoarthritis is evaluated in vitro. Sr/HCOOH-MOF is biocompatible within given doses. Furthermore, it can significantly inhibit the gene expression of IL-1β, iNOS and RANKL. Therefore, Sr/HCOOH-MOF could be a promising compound for attenuating osteoarthritis more than a drug delivery system.