医学
甲状腺机能正常
胎儿
怀孕
特拉布
脐带血
丙基硫氧嘧啶
内科学
甲状腺肿
内分泌学
产科
甲状腺切除术
格雷夫斯病
甲状腺
遗传学
生物
作者
Michel Polak,Juliane Léger,Dominique Luton,J.-F. Oury,E. Vuillard,C. Boissinot,P Czernichow
出处
期刊:PubMed
日期:1997-01-01
卷期号:58 (4): 338-42
被引量:10
摘要
We described here three individual pregnancies in a euthyroid mother with a past history of Graves disease and high levels of thyrotropin receptor stimulating antibodies. Ten years prior to her first pregnancy the mother underwent a partial thyroidectomy for Graves disease and remained euthyroid since, but still produced high levels of thyrotropin receptor stimulating antibodies. Fetal and postnatal hyperthyroidism was not recognized for the first child who was referred to us at one year of age for craniostenosis. During the two next pregnancies fetal hyperthyroidism was suspected on the basis of fetal tachycardia, growth retardation, fetal goiter and fetal cord blood sampling confirmed high levels of free T3, free T4, suppressed fetal TSH levels, and high levels of fetal TRAb. The mother received propylthiouracil to control fetal hyperthyroidism. Neither baby was premature and each had a more favorable outcome than the first. Fetal cord blood sampling proved to be useful during these two pregnancies to ascertain the diagnosis of fetal hyperthyroidism and to monitor the dose of PTU administered to this euthyroid mother.
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