血脑屏障
多西紫杉醇
药物输送到大脑
化学
细胞毒性
药理学
药物输送
胶质瘤
渗透
体外
谷胱甘肽
生物物理学
癌症研究
医学
癌症
生物化学
中枢神经系统
生物
内科学
有机化学
酶
膜
作者
Aditya Grover,Anjali Hirani,Yashwant Pathak,Vijaykumar Sutariya
出处
期刊:Aaps Pharmscitech
[Springer Nature]
日期:2014-08-19
卷期号:15 (6): 1562-1568
被引量:53
标识
DOI:10.1208/s12249-014-0165-0
摘要
Gliomas are some of the most aggressive types of cancers but the blood–brain barrier acts as an obstacle to therapeutic intervention in brain-related diseases. The blood–brain barrier blocks the permeation of potentially toxic compounds into neural tissue through the interactions of brain endothelial cells with glial cells (astrocytes and pericytes) which induce the formation of tight junctions in endothelial cells lining the blood capillaries. In the present study, we characterize a glutathione-coated docetaxel-loaded PEG-PLGA nanoparticle, show its in vitro drug release data along with cytotoxicity data in C6 and RG2 cells, and investigate its trans-blood–brain barrier permeation through the establishment of a Transwell cellular co-culture. We show that the docetaxel-loaded nanoparticle’s size enables its trans-blood–brain barrier permeation; the nanoparticle exhibits a steady, sustained release of docetaxel; the drug is able to induce cell death in glioma models; and the glutathione-coated nanoparticle is able to permeate through the Transwell in vitro blood–brain barrier model.
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