胶质纤维酸性蛋白
GFAP染色
老年斑
星形胶质细胞
阿尔茨海默病
病理
痴呆
老年痴呆
退行性疾病
化学
医学
神经科学
生物
疾病
免疫组织化学
中枢神经系统
作者
Philip E. Duffy,Maurice M. Rapport,Liselotte Graf
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:1980-07-01
卷期号:30 (7): 778-778
被引量:174
摘要
Glial fibrillary acidic protein (GFAP), a protein that is associated with 9-nm filaments of astrocytes, was observed to be increased in the astrocytes surrounding senile plaques in patients with Alzheimer dementia and in aged subjects without dementia. A few GFAP-positive fibers were seen in the centers of plaques. These results emphasized the selectivity of senile changes; whereas some cells seemed to undergo degeneration or dysfunction, other cells--astrocytes--maintain their capacity for reaction and may increase the formation of at least one protein, GFAP.
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