纳米载体
介孔二氧化硅
纳米颗粒
药物输送
动态光散射
核化学
介孔材料
材料科学
多重耐药
化学工程
纳米技术
化学
有机化学
生物化学
工程类
催化作用
抗生素
作者
Mengmeng Shao,Cong Chang,Zuhao Liu,Kai Chen,Yimin Zhou,Guohua Zheng,Zhijun Huang,Haixing Xu,Ping Xu,Bo Lü
标识
DOI:10.1016/j.colsurfb.2019.110427
摘要
A nanocarrier system of methoxypolyethylene glycol amine (mPEG-NH2) functionalized polydopamine (PDA) coated hollow mesoporous silica nanoparticles (HMSNs-PDA-PEG) was developed with pH-responsive, which combined doxorubicin hydrochloride (DOX) and quercetin (QUR) to reverse multidrug resistance (MDR) and improved anticancer effects on taxol (TAX) and DOX double resistant human colorectal cancer cell line HCT-8 (HCT-8/TAX cells). Well-dispersed nanoparticles (HMSNs-PDA-PEG) were prepared with a dimension of around 170 nm. The surface morphology and chemical properties of HMSNs-PDA-PEG were also successfully characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET) method, Fourier transform infrared spectroscopy (FT-IR) and dynamic light scattering (DLS). Drug release experiments results indicated that DOX and QUR (QD) loaded nanoparticles ([email protected]) had similar release kinetic profiles of each drug, which all exhibited highly sensitive to pH value due to the surface PDA coating. Additionally, the HCT-8 cells or HCT-8/TAX cells were employed to assess the cellular uptake and cytotoxicity of various drug-free or drug-loaded HMSNs samples. Meanwhile, a series of biological evaluations demonstrated that the [email protected] exhibited remarkable ability to overcome MDR compared with free DOX and [email protected] Taken together, these results revealed that [email protected] was suitable as a prospective and efficient drug delivery nanosystem for overcoming multidrug resistance.
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