药物输送
生物相容性
纳米技术
肽
生物相容性材料
组织工程
适应性
生化工程
化学
材料科学
生物物理学
生物医学工程
生物化学
工程类
生物
有机化学
生态学
作者
Afzal Shah,Maria Saleem Malik,Gul N. Khan,Erum Nosheen,Faiza Jan Iftikhar,Farman Ali Khan,Shyam S. Shukla,Mohammad Salim Akhter,Heinz‐Bernhard Kraatz,Tejraj M. Aminabhavi
标识
DOI:10.1016/j.cej.2018.07.126
摘要
Stimuli-responsive proteins have gained a wide spread interest as functional biomaterials in drug delivery area. However, particular attention has been diverted to peptide-based materials due to their adaptability and reliable practical utility in biomedical applications under a range of physiological situations. Peptides exhibit a high degree of chemical and biophysical versatility, biocompatibility, and biodegradability compared to other responsive systems. Several peptide motifs have been identified to undergo significant changes in conformation as a result of their response to both internal and external stimuli including light, pH, temperature, enzymes, ionic species and redox reactions. Understanding the structure and functions of peptides both at micro and macro levels is necessary before they can be used as nano devices, as biosensors, in regenerative tissue engineering and in drug delivery. The present review provides an overview of the peptide-based stimuli responsive materials, their design and discussion of their potential setbacks and opportunities for further exploration in drug delivery applications. The design of peptide-based materials of desired architectures, their properties and potential applications will be discussed covering the literature of the past decade, with a focus on their responsiveness to external and internal stimuli.
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