生物医学中的光声成像
胶质母细胞瘤
脑瘤
癌症研究
分子成像
血脑屏障
化学
医学
体内
神经科学
病理
生物
中枢神经系统
光学
物理
生物技术
作者
Xingang Liu,Yukun Duan,Dehong Hu,Min Wu,Chengjian Chen,Pramila Ghode,Gayathiri Magarajah,Nitish V. Thakor,Xin Liu,Chengbo Liu,Zonghai Sheng,Bin Liu
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2021-07-30
卷期号:3 (9): 1284-1290
被引量:13
标识
DOI:10.1021/acsmaterialslett.1c00329
摘要
The delivery of imaging agents to brain tumor sites has been a longstanding hindrance, because of the presence of blood-brain barriers (BBB) and the complex brain tumor microenvironment. The living cell-based delivery system has shown tantalizing prospects for therapeutic applications targeting oncological diseases. Herein, we design a lipid-decorated molecular photoacoustic contrast agent TFML, which can effectively label harvested live neutrophils without affecting the activation and transmigration functions. After labeling neutrophils with TFML probes, TFML-labeled neutrophil (TFML-NE) was adoptively transferred into the recipient body and demonstrated strong PA signals, good brain tumor-targeting capability, and was applied for mice glioblastoma multiforme (GBM) detection. The successful development of TFML probes for neutrophil labeling and brain tumor targeting PAI presents a promising prospect for neutrophil-based nanotherapeutics studies.
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