Polymer-Immobilized Catalyst for Asymmetric Hydrogenation of Racemic α-(N-Benzoyl-N-methylamino)propiophenone

Asymmetric hydrogenation of alpha-(N-benzoyl-N-methylamino)propiophenone through dynamic kinetic resolution was performed by using a polymer-immobilized chiral diamine-ruthenium-BINAP-t-BuOK system in order to yield syn-beta-amide alcohol exclusively with nearly perfect enantioselectivity.