血管生成
免疫疗法
癌症研究
癌症免疫疗法
肿瘤微环境
免疫检查点
转移
癌细胞
腺苷
癌症
免疫系统
下调和上调
医学
生物
免疫学
内科学
生物化学
基因
作者
Ghasem Ghalamfarsa,Mohammad Hossein Kazemi,Sahar Raoofi Mohseni,Ali Masjedi,Mohammad Hojjat‐Farsangi,Gholamreza Azizi,Mehdi Yousefi,Farhad Jadidi‐Niaragh
标识
DOI:10.1080/14728222.2019.1559829
摘要
Introduction: Cancer cells apply various mechanisms to induce and enhance immune escape. The complex network of immune-response modulating factors in the tumor microenvironment is a reason for the difficulties encountered when attempting to treat many cancers. Adenosine is a potent immune-modulating factor that can be generated through the degradation of ATP by cooperative action of NTPDase1 (CD39) and ecto-5ʹ-nucleotidase (CD73) molecules. Overexpression of CD73 on tumor and immune cells leads to the presence of a high concentration of this factor in the tumor region. Upregulation of CD73 is associated with the overproduction of adenosine; it suppresses antitumor immune responses and helps proliferation, angiogenesis, and metastasis.Areas covered: We attempt to clarify the immunobiology of CD73 in association with its role in cancer development, angiogenesis, and metastasis. Moreover, we have reviewed CD73-targeting studies and highlighted CD73 as a potent target for cancer immunotherapy.Expert opinion: It seems that blockade of CD73, in combination with immune checkpoint inhibitors such as anti-PD-L1 and anti-CTLA-4, can be a novel promising therapeutic strategy that can be evaluated in the future trials.
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