生物膜
细菌
微生物学
细胞外基质
化学
胞外聚合物
抗菌剂
生物
细胞生物学
遗传学
作者
Angela Di Somma,Antonio Moretta,Carolina Cané,Arianna Cirillo,Angela Duilio
出处
期刊:IntechOpen eBooks
[IntechOpen]
日期:2020-10-07
被引量:13
标识
DOI:10.5772/intechopen.90614
摘要
Biofilm is a complex matrix consisting of extracellular polysaccharides, DNA, and proteins that protect bacteria from a variety of physical, chemical, and biological stresses allowing them to survive in hostile environments.Biofilm formation requires three different stages: cell attachment to a solid substrate, adhesion, and growth.The inhibition of one of these steps by small molecules, such as antimicrobial peptides, or their action on specific targets will leave pathogens armless against classical antibiotics.Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance.In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drugresistant strains.
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