卵母细胞
细胞生物学
卵泡液
毛囊
卵泡
细胞外
小泡
生物
细胞内
胚胎
体细胞
胚胎发生
胞外囊泡
卵泡发生
细胞外小泡
化学
卵泡期
微泡
内分泌学
生物化学
膜
小RNA
基因
作者
Ana Clara Faquineli Cavalcante Mendes de Ávila,Juliano Coelho da Silveira
摘要
The follicle is a dynamic microenvironment in the ovary where the oocyte develops. Intercellular communication between somatic cells and the oocyte inside the follicle is essential to generate a competent gamete. Extracellular vesicles are nanoparticles secreted by cells that mediate cell-to-cell communication in the follicle microenvironment and can be obtained from the follicular fluid. These extracellular vesicles have been studied as biomarkers and supplementation tools to mimic physiological conditions during assisted reproductive techniques because they are vehicles of bioactive molecules. Therefore, this paper reviews the importance of changes in the ovarian follicle and the effects of extracellular vesicles from follicular fluid during oocyte maturation and early embryo development. Finally, we propose that is important to consider the source of the extracellular vesicles to improve diagnostic methods and to increase invitro embryo production.
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